Studies Investigate the Impact of Obesity on Outcomes after the Total Ankle Replacement (TAR) Procedure


Foot and ankle orthopaedic surgeons still evaluating the impact of obesity on the procedure’s success

Rosemont, Ill., Oct. 17, 2023 (GLOBE NEWSWIRE) — Total Ankle Replacement (TAR), also known as total ankle arthroplasty, is a surgical procedure that foot and ankle orthopaedic surgeons use to treat ankle arthritis. In the procedure, the ankle joint is removed and replaced with an artificial implant made of metal and plastic. The goal of TAR is to provide pain relief while preserving ankle motion so the patient has less pain and better function during activity. Foot and ankle orthopaedic surgeons continue to investigate the factors that contribute to the success or failure of the procedure, including the impact of obesity. 

In a recent study published in the Foot & Ankle International (FAI) scientific journal, researchers from Duke University in Durham, North Carolina, reviewed the impact of obesity on patient-reported outcomes and complication rates after the TAR procedure. The study titled “Total Ankle Arthroplasty: Does Obesity Matter?” reviewed data from 1,093 patients who underwent TAR at Duke between 2001 and 2020. Patients were grouped by body mass index (BMI) including a control group, an obesity class I with a BMI from 30-34.9, and an obesity class II with a BMI of 35 and over.  


Albert T. Anastasio, MD, of Duke University, one of the study’s authors, said the researchers did not see any increase in complication rates or failure rates across all three obesity classes after the TAR procedures. This is one of the largest single-institution studies to date examining the effect of obesity on outcomes after TAR.

Yet, results from other studies have shown that obesity does impact the procedure’s success. In a separate study published in FAI, researchers from the United Kingdom analyzed various risk factors for TAR failure in a retrospective registry-based study of 5,562 patients. They reported that increased BMI significantly increased the risk of TAR failure.

Both studies used larger data samples for their evaluations, yet they had very different findings. In an expert commentary in FAI, independent researchers reviewed these results.

“I was surprised that two studies with large sample sizes came to different conclusions regarding complication rates in obese patients that have undergone a TAR,” said Timothy R. Daniels, MD, FRCSC, chief of the Division of Orthopaedic Surgery at St. Michael’s Hospital in Toronto, Canada, who co-authored the commentary. “These conflicting outcomes suggest that a more in-depth analysis is required in order to identify the reasons for this disparity.”

“Dr. Daniels’ commentary is a fantastic interpretation of the literature,” Dr. Anastasio said.  “Simply, we do not yet know the answer on whether obese patients fare worse after the TAR procedure. The data is clearer with other forms of total joint replacement like hip and knee replacement – we are still learning a lot about ankle replacements.”  

Dr. Anastasio added, “My take-home point would be to offer folks hope that TAR can be as successful in patients with elevated BMIs. We really saw an impressive reduction in pain and improvements in function in both normal BMI and elevated BMI patients in our study.”

Drs. Anastasio and Daniels agree that future studies with larger samples are required to fully understand the impact of obesity after TAR.

Both studies and the expert commentary appeared in the July 2023 issue of Foot & Ankle International, the official journal of the American Orthopaedic Foot & Ankle Society (AOFAS). FAI is published by SAGE Journals.

About Foot and Ankle Orthopaedic Surgeons
Foot and ankle orthopaedic surgeons are medical doctors (MD and DO) who specialize in the diagnosis and treatment of musculoskeletal disorders and injuries of the foot and ankle. Their education and training consist of four years of medical school, five years of postgraduate residency, and a fellowship year of specialized surgical training. These specialists care for patients of all ages, performing reconstructive surgery for deformities and arthritis, treating sports injuries, and managing foot and ankle trauma.

About the AOFAS
The American Orthopaedic Foot & Ankle Society (AOFAS) mobilizes our dynamic community of foot and ankle orthopaedic surgeons to improve patient care through education, research, and advocacy. As the premier global organization for foot and ankle care, AOFAS delivers exceptional events and resources for continuous education, funds and promotes innovative research, and broadens patient understanding of foot and ankle conditions and treatments. By emphasizing collaboration and excellence, AOFAS inspires ever-increasing levels of professional performance leading to improved patient outcomes. For more information visit the American Orthopaedic Foot & Ankle Society online at

About Foot and Ankle International

Foot & Ankle International (FAI), published since 1980, is the official journal of the American Orthopaedic Foot & Ankle Society (AOFAS). This monthly medical journal emphasizes surgical and medical management as it relates to the foot and ankle with a specific focus on reconstructive, trauma, and sports-related conditions utilizing the latest technological advances. FAI offers original, clinically oriented, peer-reviewed research articles presenting new approaches to foot and ankle pathology and treatment, current case reviews, and technique tips addressing the management of complex problems. Learn more:

CONTACT: Elizabeth Edwards American Orthopaedic Foot & Ankle Society (AOFAS) 618-795-4824 [email protected] 

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